One of the main concerns of the west was the significant threat Iraq posed to Saudi Arabia. Following the conquest of Kuwait, the Iraqi army was within easy striking distance of Saudi oil fields. Control of these fields, along with Kuwaiti and Iraqi reserves, would have given Hussein control over the majority of the world's oil reserves. Iraq also had a number of grievances with Saudi Arabia. The Saudis had lent Iraq some 26 billion dollars during its war with Iran. The Saudis backed Iraq, as they feared the influence of Shia Iran's Islamic revolution on its own Shia minority (most of the Saudi oil fields are in territory populated by Shias). After the war, Saddam felt he should not have to repay the loans due to the help he had given the Saudis by stopping Iran.

Soon after his conquest of Kuwait, Hussein began verbally attacking the Saudi kingdom. He argued that the U.S.-supported Saudi state was an illegitimate and unworthy guardian of the holy cities of Mecca and Medina. He combined the language of the Islamist groups that had recently fought in Afghanistan with the rhetoric Iran had long used to attack the Saudis.

Acting on the policy of the Carter Doctrine, and out of fear the Iraqi army could launch an invasion of Saudi Arabia, U.S. President George H. W. Bush quickly announced that the U.S. would launch a "wholly defensive" mission to prevent Iraq from invading Saudi Arabia under the codename Operation Desert Shield. Operation Desert Shield began on 7 August 1990 when U.S. troops were sent to Saudi Arabia due also to the request of its monarch, King Fahd, who had earlier called for U.S. military assistance. This "wholly defensive" doctrine was quickly abandoned when, on 8 August, Iraq declared Kuwait to be the 19th province of Iraq and Saddam Hussein named his cousin, Ali Hassan Al-Majid as its military-governor.

The United States Navy mobilized two naval battle groups, the aircraft carriers USS Dwight D. Eisenhower, USS Independence and their escorts, to the area, where they were ready by 8 August. A total of 48 U.S. Air Force F-15s from the 1st Fighter Wing at Langley Air Force Base, Virginia, landed in Saudi Arabia, and immediately commenced round the clock air patrols of the Saudi–Kuwait–Iraq border areas to discourage further Iraqi military advances. They were joined by 36 F-15 A-Ds from the 36th TFW at Bitburg, Germany. The Bitburg contingent was based at Al Kharj Air Base, approximately 1 hour southeast of Riyadh. The 36th TFW were responsbile for 11 confirmed Iraqi Air Force aircraft shot down during the war. The U.S. also sent the battleships USS Missouri and USS Wisconsin to the region. Military buildup continued from there, eventually reaching 543,000 troops, twice the number used in the 2003 invasion of Iraq. Much of the material was airlifted or carried to the staging areas via fast sealift ships, allowing a quick buildup.