The Persian Gulf War or First Gulf War started with an extensive aerial bombing campaign on 17 January 1991. The coalition flew over 100,000 sorties, dropping 88,500 tons of bombs, and widely destroying military and civilian infrastructure. The air campaign was commanded by USAF Lieutenant General Chuck Horner, who briefly served as Commander-in-Chief - Forward of U.S. Central Command while General Schwarzkopf was still in the United States.

A day after the deadline set in Resolution 678, the coalition launched a massive air campaign, which began the general offensive codenamed Operation Desert Storm. The first priority for Coalition forces was the destruction of the Iraqi air force and anti-aircraft facilities. The sorties were launched mostly from Saudi Arabia and the six Coalition aircraft carrier battle groups (CVBG) in the Persian Gulf and Red Sea.

The next coalition targets were command and communication facilities. Saddam Hussein had closely micromanaged the Iraqi forces in the Iran–Iraq War, and initiative at lower levels was discouraged. Coalition planners hoped that Iraqi resistance would quickly collapse if deprived of command and control.

The third and largest phase of the air campaign targeted military targets throughout Iraq and Kuwait: Scud missile launchers, weapons research facilities, and naval forces. About one-third of the Coalition airpower was devoted to attacking scuds, some of which were on trucks and therefore difficult to locate. Some U.S. and British special forces teams had been covertly inserted into western Iraq to aid in the search and destruction of Scuds.

Iraqi antiaircraft defenses, including MANPADs, were surprisingly ineffective against coalition aircraft and the coalition suffered only 75 aircraft losses in over 100,000 sorties, 44 of which were the result of Iraqi action. Two of these losses are the result of aircraft colliding with the ground while evading Iraqi ground fired weapons. One of these losses is a confirmed air-air victory.